Article from Life Sciences, used Spiders-Web building patterns to determine Toxicity in such Chemicals, Marijuana, Benzedrine, Caffeine, and Chloral Hydrate.
Spiders who had been given marijuana started out well enough, but were unable to maintain focus. According to the National Institute on Drug Abuse, the main effects of marijuana on mood vary and may include euphoria, calmness, anxiety, or paranoia. Getting high or "stoned" is the reason most pot smokers use marijuana.
Benzedrine (speed) produced spiders who spun enthusiastically, though no great thought or care was put into the web design. Early users of the Benzedrine inhaler discovered it had a euphoric stimulant effect, resulting in its being one of the earliest synthetic stimulants to be widely used for recreational (i.e., nonmedical) purposes.
Caffeine, one of the most common stimulants taken by humans, produced an erratic web. Caffeine is a stimulant to the central nervous system, and regular use of caffeine does cause mild physical dependence. But caffeine doesn't threaten your physical, social, or economic health the way addictive drugs do.
Chloral hydrate, an ingredient in sleeping pills, made the spiders doze off after barely getting started on the web. Chloral hydrate is produced from chlorine and ethanol in acidic solution. In basic conditions the haloform reaction takes place and chloral hydrate is decomposed by hydrolysis to form chloroform. Not FDA approved.
Though this 1995 experiment sought to determine toxicity of drugs, it was a continuation of experimentation of spiders on drugs that had started in 1948 by P. N. Witt.
Interpretive video of the effects of Drugs on Spiders. Thanks Canada.